It has the potential to do away with chemotherapy, surgery and radiation treatment.
I read that as: Will never reach the market because it threatens a multibillion dollar industry.
But srsly, glioblastoma is a really nasty motherfucker with a very low patient survival rate, so if they’ve really managed to cure it that’s a huge milestone.
I’ll read the publication in the coming days and report back, but don’t get your hopes up. There’s a “breakthrough” in cancer research every few months and it leads to nothing. And this study was done in mice which are a bit different to humans (citation needed)
They cured hair loss in mice at least twenty times now and we still have bald humans
They should probably find a way to turn humans into mice. It’s a shame to leave billions of dollars on the table like that.
Might be a good concept for a sci fi story actually, probably a comedic one. Scientists learn how to cure any disease and reverse aging, but only for mice. Conveniently for plot reasons, they also figure out how to turn people into mice and back. You can get any disease cured or become young again…but you have to spend three months as a mouse.
Someone that knows what they’re doing: I will watch this show.
Is Anne Hathaway coming back as the grand witch?
I know of a short story on becoming a mouse, but that one’s focus is something euthanasia adjacent.
I cannot remember what but I’ve heard of mention of a story where because there’s so many cures of disease for mice that they take over the world or something. It’s such a faint mention sorry
Pinky and the Brain. Obviously.
Fuck that, just implant those mice on my scalp.
Why do we not simply transplant the hair from the mice, onto the humans?
To avoid rejection of the hair follicles, simply glue live mice to the top of your head.
This sounds like a ChatGPT response from the early days.
Gonna need a Lotta mice
At least 3
“Mice lie and monkeys exaggerate.”
That’s cause they’re not on dutasteride, finasteride, or estrogen therapy. It’s all the fault of DHT.
We have hair loss cures for humans too, the main roadblock for use is men like functioning balls.
I take finasteride and my balls are functioning
I think this is overly negative. There have been multiple significant advances in cancer treatment over the past 10 years. It just depends which type you get.
Maybe overly negative by saying they come to “nothing”, but if you trace those advances back to their initial press release stage, they generally way ovehype it.
Here we have what is being heralded as maybe a universal response to any and all cancer. That would be a shockingly amazing deviation from basically all the cancer research to date. It’s possible and wonderful if true, but generally the research falls short of the initial press coverage, even if it amounts to something.
while you’re not wrong i do want to reiterate that mRNA vaccines are likely going to be how we treat and cure cancers so there is precedent at least for this to be massive news. if not this there will likely be a real announcement one day.
The likelihood that all cancers express a common surface marker that is never expressed by any non-cancerous cell seems pretty low. Not a cancer biologist, but there’s all kind of different genetic paths to cancer - why would they all cause some specific molecule to be expressed and why would no other cell ever use it?
Your instincts are correct. The approach in the paper is more complicated than this. Here is the abstract:
Abstract The success of cancer immunotherapies is predicated on the targeting of highly expressed neoepitopes, which preferentially favours malignancies with high mutational burden. Here we show that early responses by type-I interferons mediate the success of immune checkpoint inhibitors as well as epitope spreading in poorly immunogenic tumours and that these interferon responses can be enhanced via systemic administration of lipid particles loaded with RNA coding for tumour-unspecific antigens. In mice, the immune responses of tumours sensitive to checkpoint inhibitors were transferable to resistant tumours and resulted in heightened immunity with antigenic spreading that protected the animals from tumour rechallenge. Our findings show that the resistance of tumours to immunotherapy is dictated by the absence of a damage response, which can be restored by boosting early type-I interferon responses to enable epitope spreading and self-amplifying responses in treatment-refractory tumours.
Eh a lot of them save some lives. Its just cancer is really good at killing people and there are a lot of types of cancer
It’s why I start following it myself when it gets to the human trial stage and less the breakthrough stage. There, you make the assumption that they have a plan and are much more confident in the product.
I will remain eternally hopeful! Maybe someday. Maybe!
How about fusion power and room temperature superconductors…
ITER is still well under way as far as fusion goes. I doubt room temp super conductors will ever be a thing though. If we can get a metalic material which superconducts above the boiling point of nitrogen then that will be world changing enough.
LOL. ITER is not and has never been meant to be a fusion power plant. That would be DEMO.
Don’t hold your breath.
https://en.wikipedia.org/wiki/DEMOnstration_Power_Plant
Fusion power will never, ever happen. Ever.
Look at CFS SPARC, not ITER
They will have an actual functioning fusion machine with Q>10 by end of this year thanks to high temperature superconductors that were not available when ITER started
Thanks for the laugh!
I’ve put a note in my calendar for December 2025.
Yeah just wait for the oil/LNG and helium reserves to run out. 🫠
Yes, I’m sure something as simple and resource-light as a fusion reactor will be exactly the thing we’ll be able to build when the oil runs out.
Oil/LNG not likely to be exhausted in our lifetime, nor do we seem to have the global political willpower to do enough about climate change or perturb capital. Furthermore, the article talks about a lack of VC finding making it unlikely to be viable in the mean time. This is the basis of the sardonic statement in agreement with your comment but also intending to cast a political light on the concern from my end.
Oil/LNG not likely to be exhausted in our lifetime,
Indeed not, but that EROEI is going towards 1, and maybe even <1. That’s not the same type of civilization any more. One sends people to play golf on the Moon to impress the neighbors.
The other densifies its cities in desperation hoping the food doesn’t run out.
Rfk is about to wake up and fire everyone doing this research.
When we say “healthcare” we mean caring for the health of healthcare corporations.
Too bad we got a Sociopathic Oligarchs as HSS, who thinks mRNA vaccines should be banned. Cancer is better than…well, whatever is wrong with mRNA vaccines.
Hopefully, the researchers will be fully employed by the EU. I wouldn’t trust the US to not fuck up this miracle.
“How much would you pay to not die of a tumour?”
Previous research has focused more on homing in on a target or tailoring a vaccine specific to a patient’s own cancer profile.
“This study suggests a third emerging paradigm,” said study co-author Duane Mitchell, MD. “What we found is by using a vaccine designed not to target cancer specifically but rather to stimulate a strong immunologic response, we could elicit a very strong anticancer reaction. And so this has significant potential to be broadly used across cancer patients – even possibly leading us to an off-the-shelf cancer vaccine.”
So… Kinda triggering your own auto-inmune response. But I’d be wary of trouble with overtly aggressive auto-inmune responses, as we already have quite a few diseases coming from these, as well.
I guess if I was gonna die and absolutely wanted more time I would make the trade off for living with lupus
living with lupus
As someone with an autoimmune disorder, I’m honestly not all that sold on whether that’s a good tradeoff.
Yay, you’re not acutely dying of cancer, but now your body is attacking your internal organs and depending on how shitty your luck is, you can eg. look forward to liver and/or kidney transplants (possibly more than once, too)
It’s never lupus.
Multiple Sclerosis comes to mind
Superbugs are gonna look like regular bugs.
Immune checkpoint inhibitors are already a relatively common therapy for several types of cancer.
This sounds like the intro plot to one of those zombie movies…
Because Hollywood is so insanely bad at portraying science even remotely accurately, literally everything sounds like the plot to a zombie movie.
I’m not even kidding, I’m not in the biotech field and even I feel my eye twitch every time I see a movie with zombified lab animals smacking into the bars of their cages as the plucky heroes try to unravel what vile sins against nature those evil researchers uncovered in their hubris.
Yeah i’ve had RA since i was 12, that explaination of function just made my brain screech
I’m gonna be watching with popcorn when anti-vaxxers get cancer and definitely 100% will take this vaccine.
I mean, if it’s true and not just shit science reporting that I assume it is.
amazing. i can already hear the anti vax crowd seething lol
I can’t want to never hear about this again
What is the catch?
We’ll find out in 30 years
It causes cancer.
Whatatweest!
A fellow Robot Chicken connoisseur, I see! You have very good taste.
Besides that, I assume it comes at the cost of…unintended consequences for the body
As all medicines do, we still take medicine because it’s good for us in most situations when needed.
The ol’ cure the disease by killing the patient technique. Classic
Conservatives will somehow find a way to level this as devil worshiping blasphemy and let their children die of brain cancer instead.
This is how I Am Legend starts.
Win/win I love people that slap Chris Rock
What? Why?
While the formulation isn’t unlike the Covid-19 vaccine, which uses lipid nanoparticles to deliver the genetic instructions to the body, it is still somewhat different. Instead of the drug encoding a virus protein, it sends a message to the immune system to rally the troops. It essentially tells the body to produce certain proteins that stimulate the immune system – including a protein within cancer cells known as PD-L1 (Programmed Death-Ligand 1), which makes tumors become more visible to immune cells.
TLDR: they are finding that it’s more effective to make cancer more visible and have the body’s immune system do its thing.
In this study on mice…
Took them 7 paragraphs to get around to mentioning that.
But this was based on their treatment of glioblastoma working in humans, and is a modified version of that one.
Any cancer? How does this work with people who have gene mutations that suppress cancer-fighting defence systems.
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