• daannii@lemmy.worldEnglish
    413·
    2 days ago

    These drugs release endorphins not dopamine.

    Dopamine is not a feel-good neurotransmitter.

    It’s widely misunderstood and misapplied.

    Dopamine in the brain is actually more tied into motor control and function.

    A loss of dopamine producing neurons causes Parkinson’s. Interestingly, giving parkinson patients drugs to boost dopamine gives them schizophrenia like symptoms. Dopamine is not related to the reward feeling. Please stop pushing this narrative. It’s probably one of the most annoying misunderstanding of modern neuroscience in the last few years.

    Dopamine is implicated in part of the reward pathway but it is not the reward feeling.

    Instead it is part of conditioning expectations for drug use related to behaviors that get the drug.

    It’s kind of complicated but again. It 100% is not a feel-good neurotransmitter.

    It is not what makes you enjoy anything.

    You are getting confused with endorphins.

    And euphoric effects of drugs. Which are independent from dopamine.

      • daannii@lemmy.worldEnglish
        2·
        17 hours ago

        Nope.

        That’s endorphins.

        Dopamine works in the background to condition motor behaviors to seek out the reward. It’s not the reward. It’s not a feeling or emotion.

      • daannii@lemmy.worldEnglish
        4·
        16 hours ago

        That depends on theee things.

        The dosage and the person’s tolerance. And genetics.

        Drugs that are ranked higher for drug addiction typically have strong fast effects and fast loss of the high.

        But all drugs have addiction capabilities because of how tolerance in the body works. Tolerance, withdrawal, addiction. All part of the same process.

        So back to addiction.

        Cocaine. Immediate and intense high. But doesnt last that long. Same for the heroine.

        Drugs like meth and adderall are basically exactly like cocaine in many ways except the high is actually more mild (per dose) and lasts longer.

        Opiate medications can be seen as similar to heroine but. Last longer and not as strong.

        Of course you can take larger doses of either of those two and get a stronger effect.

        Even if you don’t tho, people still get addicted to both of these more milder forms of cocaine and heroine. But just not at the same risk level.

        And the risk declined drastically if taken at therapeutic levels (like following prescription drug directions).

        Another thing you have to consider is genetics in brain receptors.

        Some people’s brain responds strongly in eurphoria to a drug while someone else’s does not.

        For example. Opiates. I personally do not get euphoria from opiates. I instead get a bad headache and extreme nausea. I had an injection of morphine about a year ago for a ER visit. Not only did it not help the pain at all, I had unpleasant effects from the drug. I was not high. But I was woozy. It was incredibly awful.

        I actually told them not to give me optiates because I already knew I didn’t tolerate them but that’s what I get for going to a 1 star ER.

        So how is it possible that a drug like an opiate wouldn’t make me high or at the very least block the pain I was having ?

        Genetics. My mother is the same. The part of other peoples brain that the opiate drugs bind to, will not accept the drug in my brain. Instead the drug is binding to some other receptors. Starting a cascade of signals that give me delirium, nausea, and a headache.

        They are different enough to make a drug have a completely different effect in two animals of the same species.

        It’s things like that, that make designing drug therapies incredibly difficult.

        So even when we try to give a basis run down of what drugs are highest risk, we can’t say that’s true for everyone.

        There is zero chance I could become addicted to opiate based drugs. They literally are aversive to me.

        It also means if I get injured and I’m in severe pain, there isn’t much that can be done (so pretty big trade off. Here’s hoping I don’t get a painful terminal cancer).

        So at present. Schedule 1 drugs have a specific definition. And that definition indicates a high risk of dependency.

        You can read up more about how a drug qualifies for schedule 1. And schedule 2. I think that will help you understand the system better.

  • tias@discuss.tchncs.de
    123·
    2 days ago

    The trick is to time the cocaine and crystal meth ingestion so that they peak at the same time that you orgasm, leading to an 80% * 300% * 1400% = 7460% 10700% dopamine increase.

      • arrow74@lemmy.zip
        14·
        2 days ago

        I heard there’s a flaw in the code meaning they cannot patch the old consumables and have to release a new version instead.

        It’s unclear if the pre-patch consumables will be usable after the patch or if they’ll simply be deleted.

        Imo the best move is to collect and sell to the hoarders. Not worth the risk of losing all that time I’d rather be able to buy the new stuff even if it doesn’t stack

    • lime!@feddit.nu
      31·
      2 days ago

      if you cum, snort, and puff at the same time, your body goes into recovery mode

      • sp3ctr4l@lemmy.dbzer0.comEnglish
        2·
        2 days ago

        … What?

        No.

        You just have to hold a nose boop for 10 seconds, release, then three quick headpats.

        I am fairly sure what you have described is how to simutaneously give yourself testicular torsion, a hernia, and a heart attack.

      • naeap@sopuli.xyz
        2·
        2 days ago

        Nah, after snuffing it takes a few minutes
        You can actually pretty easily time this

        The only thing is: puffed will acted more or less immediately. So you’ll need to be able to smoke while jacking off, which can lead to serious injuries, when you’re already intoxicated

        So, wouldn’t recommend to synchronize it that much ;⁠-⁠)

      • MojoMcJojo@lemmy.world
        6·
        2 days ago

        I experienced a ‘mild’ instance of this. No f’ing thank you would I ever ever want to go through that again.

        • monotremata@lemmy.caEnglish
          5·
          2 days ago

          Same. Uggh. It was a bit like a fever, but so much worse. I was absolutely freezing and couldn’t stop shaking and sweating, but I also couldn’t really manage to distract myself with anything because my brain didn’t work, so I just had to lay there and wait. There was also this overwhelming, crushing ringing sound and a feeling like old analog TV static, along with a splitting headache. Thankfully my family were around, of whom I was dimly aware, so I could tell that time was probably passing, and I could kind of gauge that I probably wasn’t getting worse, or they’d take me to a hospital or something. That’s about the limit of what I was aware of, though. It just felt like it went on a really long time. I suspect in reality it didn’t last more than a few hours. I should ask; I’m sure one of them has a clearer memory of that aspect than I do.

    • taiyang@lemmy.world
      14·
      2 days ago

      Careful, some of us on older hardware have a bug where we overflow and crash the system. My second cousin bricked his system just by stacking the last two.

    • YoSoySnekBoi@kbin.earth
      10·
      2 days ago

      I’ve been running calculations for the last 10 minutes trying to figure out where tf you got 7460% from lmao

      • tias@discuss.tchncs.de
        3·
        2 days ago

        Yeah I made a mistake. The proper calculation for an increase by 80%, then 300%, then 1400% should be

        x * ((1+0.80) * (1+3.00) * (1+14.00) - 1) =

        x*(1.8 * 4 * 15 - 1) = x*107 = 10700%

    • Rai@lemmy.dbzer0.com
      12·
      2 days ago

      Having had oodles of bad to mediocre coke in my days and then having 90+% pure (tested myself) I honestly think this graph is misleading, and coke is waaaaay higher.

      The problem is, meth dumps your serotonin and feels good by itself, while coke requires you to be doing something that dumps your sweet brain chems to really feel good-good. I don’t know the science behind it but it’s been explained to me. Doing coke and sitting around watching a show is meh. Doing blow and playing a stimulating video game or doing a project that feels good or talking your partner’s ear off (and they yours in return) about ridiculous shit feels incredible.

      But yeah. If you need to do a couple lines of coke to really feel it, it’s not good. If you’re getting zooted off a couple bumps, that’s the good stuff.

        • Rai@lemmy.dbzer0.com
          6·
          2 days ago

          Hahaha I had done it a few times during my rave phase but I was almost always disappointed. Like, you gotta do so much of it that it clogs your nose and it goes away so quickly! Then randomly an acquaintance of mine maaaany years later told me they dabbled (understatement) and I learned that almost all coke is complete garbage. A couple bumps had me zooted for like an hour. Remember kids, if it’s already a powder when it comes to you, it’s been stepped on. If you’re getting a shiny chunk that’s almost gummy-feeling, you’re in for a treat.

            • Rai@lemmy.dbzer0.com
              3·
              2 days ago

              It’s not even as expensive as people say it is. If it’s not shitty, ya don’t go through a ball in a night! My partner and I still occasionally dabble, and we maybe go through .1-.2 each for a couple hours of zoot.

              The test kits are really cool, too. You break a glass ampule and shovel in a tiiiiny bit in. The shade of dark the chemicals turn tells you the purity. I’ve seen it turn a sludgy light-brown watery poo color a long time ago… and I’ve seen it turn black since then.

              • Mike D@piefed.socialEnglish
                4·
                2 days ago

                Once I found a good supply a ball would last over a week (unless I had some leaches). Before that i occasionally got stuff that did absolutely nothing.

                Before the good supply I went home early one night without partying. Friends bought some stuff with fent in it. One friend ended up in the ER. They used paddles to get his heart started again.

                Glad to say I no longer indulge.

                • Rai@lemmy.dbzer0.com
                  3·
                  2 days ago

                  Jesus! I’m so sorry your friend went through that, that’s awful! I’m very thankful for test strips now… it’s terrifying that something so opposite can just find its way into blow.

                  I’m glad you’re safe, and I hope your friend is okay now.

                  Good on you for no longer fuckin with it. My partner and I drink too much but otherwise are mainly sober from substances—we just have some random special days every couple months where we do something fancy and fun.

  • Asetru@feddit.org
    84·
    2 days ago

    So an orgasm will reduce the dopamine level to only 80% of where it’s supposed to be? Like you come and immediately just feel a little weird and disappointed?

    Like, I get it. It’s just nice to see it in writing.