• REDACTED@infosec.pub
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      10 hours ago

      Is it? I have no clue about what counts as high but I did try out 125mg gummy bear once as a seasoned smoker and it was 8/10. The high wasn’t extreme, it was more focused on “body high” while also lasting 2x as long.

      EDIT: By body high I meant that inside “buzzing” feeling, but not losing your mind to the point you laugh for no reason or start doing dumb shit. Somewhat untypical high.

      • EmpathicVagrant@lemmy.world
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        2 hours ago

        The bioavailability of a suppository instead of edible is insane by comparison. Someone who gets a lower reaction from a ~100mg edible would get similar effects from a suppository less than half that strength because it’s being absorbed by another part of the body - different receptors stimulated and less for it to travel through.

        TLDR; if your edible tolerance is high your stomach lining is just more resistant

        • captainlezbian@lemmy.world
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          2 hours ago

          Also most people who only consume casually are fucking wrecked by 100mg edibles. When I’m not being drug tested I take like one 5-10 mg edible once or twice a month and am hit hard by it. Something in the 20-50 range is normally tolerated by folks who use more than me and have higher tolerance. The only people I know who can do 100 are stoned regularly, often to deal with chronic pain

          • EmpathicVagrant@lemmy.world
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            38 minutes ago

            This comment is correct dotcom

            I’m that last group, used to need a 100mg two capsule to make it through the day. I’m down to 2 25s a day instead but some of the mental pain still seeps through.

            My dose is ~60-80 depending on symptoms but I’m trying to break it into smaller parts to fine tune the effects

          • Siethron@lemmy.world
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            1 hour ago

            I rarely get high. Last time was 5mgs gummy and it SENT me, like I forgot how to move for a couple of hours. Back when I was in college and a borderline stoner I probably wouldn’t have even have noticed that dosage. Tolerance is a hell of a drug.

        • Corkyskog@sh.itjust.works
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          2 hours ago

          I thought edible tolerance mostly had to do with a genetic marker that dictates how much of an enzyme those peoples liver produced.

          • EmpathicVagrant@lemmy.world
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            40 minutes ago

            Sometimes genetic, sometimes you can shift it with the type (sublingual oil absorbs in the gums, bypasses the liver process which it into 11-Hydroxy thc)

            The suppository would do this too, just with a different membrane and easier to have higher doses.

            Anecdotals below •I had one patient who ate a lot of liver after he had to quit drinking, and his edible tolerance dropped •My edible tolerance dropped when I lost ~100lbs •a colleague quit all other substances and tolerance dropped there too

    • undeffeined@lemmy.ml
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      11 hours ago

      Depends hevaily on tolerance levels, no? Or would the fast absortion in the intestine make the high more potent?