Sometimes genetic, sometimes you can shift it with the type (sublingual oil absorbs in the gums, bypasses the liver process which it into 11-Hydroxy thc)
The suppository would do this too, just with a different membrane and easier to have higher doses.
Anecdotals below
•I had one patient who ate a lot of liver after he had to quit drinking, and his edible tolerance dropped
•My edible tolerance dropped when I lost ~100lbs
•a colleague quit all other substances and tolerance dropped there too
I thought edible tolerance mostly had to do with a genetic marker that dictates how much of an enzyme those peoples liver produced.
Sometimes genetic, sometimes you can shift it with the type (sublingual oil absorbs in the gums, bypasses the liver process which it into 11-Hydroxy thc)
The suppository would do this too, just with a different membrane and easier to have higher doses.
Anecdotals below •I had one patient who ate a lot of liver after he had to quit drinking, and his edible tolerance dropped •My edible tolerance dropped when I lost ~100lbs •a colleague quit all other substances and tolerance dropped there too